LEQEMBI

Generic Name/API: lecanemab-irmb

Manufacturer: Eisai Inc.

Dosage Forms & Strength & Pack Size:
Injection:
• 500 mg/5 mL (100 mg/mL) solution in a single-dose vial
• 200 mg/2 mL (100 mg/mL) solution in a single-dose vial

Storage:
Unopened Vial
• Store in a refrigerator at 2°C to 8°C (36°F to 46°F).
• Store in the original carton to protect from light.
• Do not freeze or shake.

  • INDICATION
  • IMPORTANT SAFETY INFORMATION

INDICATIONS
WHAT IS LEQEMBI?
COLLAPSE
LEQEMBI is a prescription medicine used to treat people with Alzheimer’s disease.

If you have serious allergic reactions to any of the ingredients in LEQEMBI, you should not be treated with LEQEMBI.

IMPORTANT SAFETY INFORMATION
Information icon
What is the most important information I should know about LEQEMBI?

LEQEMBI can cause serious side effects, including:
ARIA (amyloid-related imaging abnormalities). There are usually no signs of ARIA. In rare cases, it can lead to serious complications

ARIA can show up as swelling in parts of the
brain or small spots of bleeding
Larger areas of bleeding in the brain may occur, but this is uncommon
ARIA usually goes away over time
Most people with ARIA don’t have any
symptoms. However, some people
may notice:
–headache
–confusion that gets worse
–dizziness
–vision problems
–nausea
–problems walking
–seizures
Some people have a gene called ApoE4 that may increase the risk of ARIA. Talk to your healthcare provider about testing to see if you have this gene
Some medicines can increase the risk of larger areas of bleeding in the brain for people taking LEQEMBI. Talk to your healthcare provider to see if any of the medicines you’re taking increase this risk
Your healthcare provider will check for ARIA with MRI (magnetic resonance imaging) scans before you start LEQEMBI and during treatment
Before receiving LEQEMBI, tell your healthcare provider about all your medical conditions, including
if you:
are pregnant or plan to become pregnant. It is not known if LEQEMBI will harm your unborn baby. Tell your healthcare provider if you become pregnant during your treatment with LEQEMBI

are breastfeeding or plan to breastfeed. It is not known if any of the ingredients in LEQEMBI pass
into your breast milk. Talk to your healthcare provider about the best way to feed your baby

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you take medicines to reduce blood clots from forming (including aspirin). Ask your healthcare provider for a list of these medicines if you are not sure.
Keep a list of the medicines you take. Show it to your healthcare provider and pharmacist when you get a new medicine.
while receiving LEQEMBI

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Especially tell your healthcare provider if you take medicines to reduce blood clots from forming (including aspirin). Ask your healthcare provider for a list of these medicines if you are not sure.
Keep a list of the medicines you take. Show it to your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of LEQEMBI?

LEQEMBI can cause serious side effects, including:

ARIA (amyloid-related imaging abnormalities) (see above)

Serious allergic reactions may happen during a LEQEMBI infusion. Tell your healthcare provider if you notice any of these symptoms during or after a LEQEMBI infusion:

–swelling of the face, lips, mouth, or tongue
–itchy bumps on the skin, also known as hives
–difficulty breathing

Infusion bag icon
Infusion-related reactions are common and can sometimes be serious. Tell your healthcare provider right away if you notice any of these symptoms during an infusion:
–fever
–flu-like symptoms (chills, joint and body aches, feeling shaky)
–nausea and/or vomiting
–dizziness or lightheadedness
–fast or slow heart rate, or feeling like your chest is pounding
–difficulty breathing or shortness of breath

Your healthcare provider may give you medicines before your next infusion to lower the chance of having
a reaction.

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The most common side effects of LEQEMBI include:

infusion-related reactions

swelling in areas of the brain, with or without small spots of bleeding in or on the surface of the
brain (ARIA)

headache

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