DIAMICRON MR

Generic Name/API: Gliclazide

Manufacturer: Les Laboratoires Servier Industrie

Dosage Forms & Strength & Pack Size:
Tablet, 60 mg, 60’s

Diamicron 60 mg MR is a white oblong modified release tablet, scored and engraved ‘DIA 60’ on both faces.
The tablets are available in blister packed in cartons of 7, 10, 14, 15, 20, 28, 30, 56, 60, 84, 90, 100, 112,
120, 180 or 500 tablets.
Not all pack sizes may be available.

Storage:
Keep out this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the carton and the blister strip. The expiry date refers to the last day of that month.
This medicinal product does not require any special storage conditions.
Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

  • INDICATION
  • IMPORTANT SAFETY INFORMATION

Uses of the drug Diamicron MR 60mg

What is Diamicron MR 60mg? Gliclazide is a sulphonylurea, a urea derivative, used orally to lower blood sugar. Gliclazide lowers blood glucose levels by stimulating insulin secretion from the beta cells of the islets of langerhans. Increased postprandial insulin and C peptide secretion persisted after 2 years of treatment. Along with this metabolic property, Gliclazide also has hemato-vascular effects.
Drug Diamicron MR 60mg is indicated in the following cases:
Reduce blood sugar level; Treatment of type 2 diabetes in adults (when diet, exercise, and weight loss fail to keep blood sugar at an appropriate level). The drug Diamicron MR 60mg is contraindicated in the following cases:
People with hypersensitivity to Gliclazide or its components, other drugs of the sulfonylurea group or to hypoglycemic sulfonamides; People with type 1 diabetes; People with diabetic ketoacidosis, pre-coma or diabetic coma; People with severe liver or kidney disease; People who are taking the antifungal medicine Miconazole; Mother is breastfeeding.

Warnings and precautions
You should observe the treatment plan prescribed by your doctor to achieve proper blood sugar levels. This
means, apart from regular tablet intake, you observe the dietary regimen, have physical exercise and, where
necessary, reduce weight.
During gliclazide treatment regular monitoring of your blood (and possibly urine) sugar level and also your
glycated haemoglobin (HbA1c) is necessary.
In the first few weeks of treatment the risk of having redreduced blood sugar levels (hypoglycaemia) may be
increased. So particularly close medical monitoring is necessary.
Low blood sugar (Hypoglycaemia) may occur:
– if you take meals irregularly or skip meals altogether,
– if you are fasting,
– if you are malnourished,
– if you change your diet,
– if you increase your physical activity and carbohydrate intake does not match this increase,
– if you drink alcohol, especially in combination with skipped meals,
– if you take other medicines or natural remedies at the same time,
– if you take too high doses of gliclazide,
– if you suffer from particular hormone-induced disorders (functional disorders of the thyroid gland, of the
pituitary gland or adrenal cortex),
– if your kidney function or liver function is severely decreased.
If you have low blood sugar you may have the following symptoms:
headache, intense hunger, nausea, vomiting, weariness, sleep disorders, restlessness, aggressiveness, poor
concentration, reduced alertness and reaction time, depression, confusion, speech or visual disorders, tremor,
sensory disturbances, dizziness, and helplessness.
The following signs and symptoms may also occur: sweating, clammy skin, anxiety, fast or irregular heart
beat, high blood pressure, sudden strong pain in the chest that may radiate into nearby areas (angina
pectoris).
If blood sugar levels continue to drop you may suffer from considerable confusion (delirium), develop
convulsions, lose self control, your breathing may be shallow and your heart beat slowed down, you may
become unconscious.
In most cases the symptoms of low blood sugar vanish very quickly when you consume some form of sugar,
e.g. glucose tablets, sugar cubes, sweet juice, sweetened tea.
You should therefore always carry some form of sugar with you (glucose tablets, sugar cubes). Remember
that artificial sweeteners are not effective. Please contact your doctor or the nearest hospital if taking sugar
does not help or if the symptoms recur.
Symptoms of low blood sugar may be absent, less obvious or develop very slowly or you are not aware in
time that your blood sugar level has dropped. This may happen if you are an elderly patient taking certain
medicines (e.g. those acting on the central nervous system and beta blockers).
If you are in stress-situations (e.g. accidents, surgical operations, fever etc.) your doctor may temporarily
switch you to insulin therapy.
Symptoms of high blood sugar (hyperglycaemia) may occur when gliclazide has not yet sufficiently reduced
the blood sugar, when you have not complied with the treatment plan prescribed by your doctor or in special
stress situations). These may include thirst, frequent urination, dry mouth, dry itchy skin, skin infections and
reduced performance.
If these symptoms occur, you must contact your doctor or pharmacist.

If you have a family history of or know you have the hereditary condition glucose-6-phosphate
dehydrogenase (G6PD) deficiency (abnormality of red blood cells), lowering of the haemoglobin level and
breakdown of red blood cells (haemolytic anaemia) can occur. Contact your doctor before taking this
medicinal product.
Diamicron 60 mg MR is not recommended for use in children due to a lack of data.
Other medicines and Diamicron 60mg MR
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.
The blood sugar lowering effect of gliclazide may be strengthened and signs of low blood sugar levels may
occur when one of the following medicines is taken:
– other medicines used to treat high blood sugar (oral antidiabetics, GLP-1 receptor inhibitors or
insulin),
– antibiotics (e.g. sulphonamides, clarithromycin),
– medicines to treat high blood pressure or heart failure (beta blockers, ACE-inhibitors such as captopril,
or enalapril),
– medicines to treat fungal infections (miconazole, fluconazole),
– medicines to treat ulcers in the stomach or duodenum (H2 receptor antagonists),
– medicines to treat depression (monoamine oxidase inhibitors),
– painkiller or antirheumatics (phenylbutazone, ibuprofen),
– medicines containing alcohol.
The blood glucose lowering effect of gliclazide may be weakened and raised blood sugar levels may occur
when one of the following medicines is taken:
– medicines to treat disorders of the central nervous system (chlorpromazine),
– medicines reducing inflammation (corticosteroids),
– medicines to treat asthma or used during labour (intravenous salbutamol, ritodrine and terbutaline),
– medicines to treat breast disorders, heavy menstrual bleeding and endometriosis (danazol).
Diamicron 60 mg MR may increase the effects of medicines which reduce blood clotting (e.g. warfarin).
Consult your doctor before you start taking another medicinal product. If you go into hospital tell the
medical staff you are taking Diamicron 60 mg MR.
Taking Diamicron 60 mg MR with food, drink and alcohol
Diamicron 60 mg MR can be taken with food and non-alcoholic drinks.
Drinking alcohol is not recommended as it can alter the control of your diabetes in an unpredictable manner.
Pregnancy and breastfeeding
Diamicron 60 mg MR is not recommended for use during pregnancy. If you are pregnant or breast-feeding,
think you may be pregnant or are planning to have a baby while taking this medicine, inform your doctor so
that he may prescribe a more suitable treatment for you.
You must not take Diamicron 60 mg MR while you are breastfeeding.

Driving and using machines
Your ability to concentrate or react may be impaired if your blood sugar is too low (hypoglycaemia), or too
high (hyperglycaemia) or if you develop visual problems as a result of such conditions. Bear in mind that
you could endanger yourself or others (e.g. when driving a car or using machines). Please ask your doctor
whether you can drive a car if you:
– have frequent episodes of low blood sugar (hypoglycaemia),
– have few or no warning signals of low blood sugar (hypoglycaemia).
Diamicron 60 mg MR
contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact
your doctor before taking this medicine.

 

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